Sheffield Institute for
Translational Neuroscience

20.01.2015

University of Sheffield awarded £1.3 million EPSRC Project

A multi-disciplinary research team led by Professor Alejandro Frangi, of CISTIB at the University of Sheffield and including Professor Annalena Venneri, Professsor Paul Ince and Dr Robin Highley from SITraN, has been awarded £1.3 million from the EPSRC to characterise and quantify early differential alterations in brain blood transport and subsequent microstructural tissue damage with a novel MRI technique.

The project, entitled One-stop-shopocean.png microstructure-sensitive perfusion/diffusion MRI: Application to vascular cognitive impairment, will deliver MRI sequences and analysis tools to link neuropathology, neuroimaging, and biophysics, thus being optimally positioned to discover novel biomarkers of dementia onset and progression, and to understand the effects of novel drugs and treatments.

The international team includes co-investigators at the University of Manchester and University of Cardiff as well as collaborators at the University of Antwerp and CEA-NeuroSpin along with industrial partners and charities in the UK and Europe (see table below).

The 3 year project, was ranked 1st out of 5 proposals funded from 40 submissions and involves the University’s Faculty of Engineering (CISTIB and INSIGNEO), Faculty of Medicine, Dentistry and Health (SITraN and INSIGNEO) and Department of Psychology (Pre-Clinical MRI Facility), as well as charities and industrial partners from the UK and Europe.

Professor Frangi said “we are delighted by this phenomenal opportunity to contribute to the efforts to combat dementias. It is through interdisciplinary efforts like OCEAN that we will be able to develop appropriate diagnostic and staging tools for the disease. I am really proud to count for this journey with colleagues in SITraN and INSIGNEO as well as with experts in Manchester and Cardiff, and beyond.”

http://gow.epsrc.ac.uk/NGBOViewGrant.aspx?GrantRef=EP/M006328/1

Investigators

Name

Role

Institution

Frangi, Professor AF

Principal Investigator

University of Sheffield

Kennerley, Dr AJ

Co-Investigator

University of Sheffield

Parker, Professor G

Co-Investigator

University of Manchester

Venneri, Professor A

Co-Investigator

University of Sheffield

Highley, Dr R

Co-Investigator

University of Sheffield

Jones, Professor DK

Co-Investigator

Cardiff University

Taylor, Dr ZA

Co-Investigator

University of Sheffield

Wilkinson, Professor ID

Co-Investigator

University of Sheffield

Ince, Professor PG

Co-Investigator

University of Sheffield

Dr L Beltrachini

Researcher Co-Investigator

University of Sheffield

 

Project Partners

Alzheimer's Society

Hamamatsu Photonics UK Ltd

Micro Dimensions

Siemens

University of Manchester, The

CEA - Atomic Energy Commission

ESI

Novartis

University of Antwerp

IXICO Ltd

Philips

University of Cambridge

icoMetrix

University of Sheffield

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