Sheffield Institute for
Translational Neuroscience

Dr James Alix BSc(Hons), MBChB, MRCP, PhD

Senior Clinical Lecturer in Neurophysiology, University of Sheffield

Honorary Consultant Clinical Neurophysiologist, Sheffield Teaching Hospitals NHS Foundation Trust

Research Interests

My main research is focused on the development of new techniques to diagnose and monitor neuromuscular disorders. I use electrophysiological techniques in both pre-clinical and clinical settings in order to better understand how these diseases start and change over time.     

I also have a long standing interest in perinatal brain injury.   

Teaching Interest

I am module leader for the Applied Neuroanatomy & Clinical Neuroscience module on the MSc Neurology course. I also give neurophysiology lectures and demonstrations to medical students. I regularly supervise students on SSC attachments and as part of the INSPIRE research programme. I am also a personal and academic (PATS) tutor for medical students.

I am particularly keen to encourage medical students to undertake research during their time at medical school and welcome any enquiries regarding potential projects.

Current Projects

  • Use of the motor unit number index (MUNIX) to monitor disease progression in motor neurone disease
  • Use of different types of spectroscopy to monitor neuromuscular disease


  • MRC
  • Academy of Medical Sciences
  • Ryder Briggs Neuroscience Research Fund
  • Neurocare




Research Team


  • Maria Plesia (Primary supervisor)
  • Buket Sonbas (co-supervisor; Primary supervisor Prof. Visakan Kadirkamanathan)


  • Harry McDonough


Selected Publications

Jenkins TM, Alix JJ, Rao DG, Hoggard N, Bradburn M, Bigley J, McDermott CJ, Wilkinson ID, Shaw PJ (2018). Imaging muscle as a potential biomarker of denervation in motor neuron disease. J Neurol Neurosurg Psychiatry; 89(3): 248-255.

Alix JJ, Ponnusamy A, Pilling E, Hart AR (2017). An introduction to neonatal EEG. Paediatrics & Child Health; 27(3):135-142.

Neuwirth C, Burkhardt C, Alix JJ, Castro J, de Carvalho M, Gawel M, Goedee S, Grosskreutz J, Lenglet T, Moglia C, Omer T, Schrooten M, Weber M (2016). Quality control of motor unit number index (MUNIX) measurements in 6 muscles in a single subject “round robin” setup. PLOS One, 11(5): e0153948.

Alix JJ, Kandler RH, Mordekar SR. The value of long term EEG monitoring in children: a comparison of ambulatory EEG and video telemetry. Seizure. 2014;23(8):662-5.

Goodwin E, Kandler RH, Alix JJ. The value of home video with ambulatory EEG: a prospective service review. Seizure. 2014;23(6):480-2

Alix JJ, Zammit C, Riddle A, Meshul CK, Back SA, Valentino M, Fern R. Central axons preparing to myelinate are highly sensitive to ischemic injury. Ann Neurol. 2012;72(6):936-51

Alix JJ, Domingues AM. White matter synapses: form, function, and dysfunction. Neurology. 2011;76(4):397-404

Alix JJ. Clinician-scientist training: a perspective from across the pond. Ann Neurol. 2010;68(1):119-20

Alix JJ, Fern R. Glutamate receptor-mediated ischemic injury of premyelinated central axons. Ann Neurol. 2009;66(5):682-93

Professional Activities

Module Leader, Applied Neuroanatomy & Clinical Neuroscience module, MSc Neurology course, University of Sheffield

Ad hoc peer review for journals, including Muscle and Nerve and the European Journal of Neurology

Grant reviewer for Medical Research Council, Health Research Board (Ireland)


2018 – Present
Senior Clinical Lecturer in Neurophysiology, University of Sheffield
Honorary Consultant Clinical Neurophysiologist, Sheffield Teaching Hospitals NHS Foundation Trust

2015 – 2018
NIHR Academic Clinical Lecturer in Neurophysiology, University of Sheffield

2012 – 2014
Specialty Registrar in Clinical Neurophysiology, Yorkshire and the Humber Deanery

2010 – 2012
NIHR Academic Clinical Fellowship in Core Medical Training/Neurology, University of Sheffield

2008 – 2010
Academic Foundation Programme, Imperial College, London

2000 – 2008
MB/PhD programme, University of Leicester Medical School

I studied medicine at Leicester Medical School, undertaking an intercalated BSc in neuroscience (1st class Hons) before moving onto the MB/PhD programme and completing a PhD on the molecular mechanisms of perinatal white matter injury. After graduating I completed academic foundation programme training in London before moving to Sheffield, to take up an NIHR academic clinical fellowship in neurology. I then moved into clinical neurophysiology training and completed the final part of my training as an NIHR clinical lecturer.


Lord Adrian Prize, British Society for Clinical Neurophysiology, 2017

British Society for Clinical Neurophysiology Intercalation Bursary to my student H. McDonough, 2017

NIHR Academic Clinical Lectureship, University of Sheffield, 2015

NIHR Academic Clinical Fellowship, University of Sheffield, 2010

Distinction, Final Professional Examination, University of Leicester, 2008

Wellcome Trust Elective Prize, 2008

Physiology Society Studentship, 2005

Leicester Medical Research Foundation (Medisearch) Studentship, 2004

Charles Lawson Award for Intercalated Studies, University of Leicester, 2004


Department of Neuroscience
Sheffield Institute for Translational Neuroscience
University of Sheffield
Room B35
385a Glossop Road
S10 2HQ

Tel: +44 (0)114 22 22267
Fax: +44 (0)114 22 22290