Clinical Lecturer in Neurophysiology, University of Sheffield
My main research is focused on the development of new techniques to diagnose and monitor neuromuscular disorders. I use electrophysiological techniques in both pre-clinical and clinical settings in order to better understand how these diseases start and change over time.
I also have a long standing interest in perinatal brain injury.
I am module leader for the Applied Neuroanatomy & Clinical Neuroscience module on the MSc Neurology course. I also give neurophysiology lectures and demonstrations to medical students. I regularly supervise students on SSC attachments and as part of the INSPIRE research programme. I am also a personal and academic (PATS) tutor for medical students.
I am particularly keen to encourage medical students to undertake research during their time at medical school and welcome any enquiries regarding potential projects.
I am presently involved in a SOPHIA (Sampling and biomarker OPtimization and Harmonization In ALS and other motor neuron diseases) sponsored project examining the use of the motor unit number index (MUNIX) as a longitudinal biomarker in motor neuron disease. The hope is that this technique will be more sensitive at detecting disease progression than previous markers.
I am also undertaking work on the electrodiagnostic stratification of patients with motor neuron disease and contribute to a study examining the use of magnetic resonance imaging (MRI) in motor neuron disease.
Alix JJ, Hadjivassiliou M, Ali R, Slater D, Messenger AG, Rao DG. Sensory ganglionopathy with livedoid vasculopathy controlled by immunotherapy. Muscle Nerve. 2015;51(2):296-301
Alix JJ, Kandler RH, Mordekar SR. The value of long term EEG monitoring in children: a comparison of ambulatory EEG and video telemetry. Seizure. 2014;23(8):662-5.
Goodwin E, Kandler RH, Alix JJ. The value of home video with ambulatory EEG: a prospective service review. Seizure. 2014;23(6):480-2
Alix JJ, Zammit C, Riddle A, Meshul CK, Back SA, Valentino M, Fern R. Central axons preparing to myelinate are highly sensitive to ischemic injury. Ann Neurol. 2012;72(6):936-51
Alix JJ, Domingues AM. White matter synapses: form, function, and dysfunction. Neurology. 2011;76(4):397-404
Alix JJ. Clinician-scientist training: a perspective from across the pond. Ann Neurol. 2010;68(1):119-20
Alix JJ, Fern R. Glutamate receptor-mediated ischemic injury of premyelinated central axons. Ann Neurol. 2009;66(5):682-93
Module Leader, Applied Neuroanatomy & Clinical Neuroscience module, MSc Neurology course, University of Sheffield
Ad hoc peer review for journals, including Muscle and Nerve and the European Journal of Neurology.
Biography & Awards
2015 – Present:
NIHR Academic Clinical Lecturer in Neurophysiology, University of Sheffield
2012 – 2014:
Specialty Registrar in Clinical Neurophysiology, Yorkshire and the Humber Deanery
2010 – 2012:
NIHR Academic Clinical Fellowship in Core Medical Training/Neurology, University of Sheffield
2008 – 2010:
Academic Foundation Programme, Imperial College, London
2000 – 2008:
MB/PhD programme, University of Leicester Medical School
I studied medicine at Leicester Medical School, completing an intercalated BSc in neuroscience (1st class Hons) before moving onto the MB/PhD programme. I completed my PhD under the supervision of Prof. Robert Fern (now Univ. of Plymouth) on the molecular mechanisms of perinatal white matter injury. After graduating I gained further research experience in the laboratory of Prof Stephen Back (OHSU, USA) before commencing academic foundation programme training in London. Alongside clinical work I completed a research attachment with Prof. Richard Reynolds (Imperial College, London) before moving to Sheffield to take up an NIHR academic clinical fellowship. Since arriving in Sheffield I have continued my training as a clinician-scientist under the supervision of Prof. Dame Pamela Shaw.
NIHR Academic Clinical Lectureship, University of Sheffield, 2015
NIHR Academic Clinical Fellowship, University of Sheffield, 2010
Distinction, Final Professional Examination, University of Leicester, 2008
Wellcome Trust Elective Prize, 2008
Physiology Society Studentship, 2005
Leicester Medical Research Foundation (Medisearch) Studentship, 2004
Charles Lawson Award for Intercalated Studies, University of Leicester, 2004
Academic Neurology Unit
Department of Neuroscience
Sheffield Institute for Translational Neuroscience
University of Sheffield
385a Glossop Road
Tel: +44 (0)114 22 222
Fax: +44 (0)114 22 22290