Sheffield Institute for
Translational Neuroscience

Dr James Alix BSc(Hons), MBChB, MRCP, PhD

Clinical Lecturer in Neurophysiology, University of Sheffield

Research Interests

My main research is focused on the development of new techniques to diagnose and monitor neuromuscular disorders. I use electrophysiological techniques in both pre-clinical and clinical settings in order to better understand how these diseases start and change over time.     

I also have a long standing interest in perinatal brain injury.   

Teaching Interest

I am module leader for the Applied Neuroanatomy & Clinical Neuroscience module on the MSc Neurology course. I also give neurophysiology lectures and demonstrations to medical students. I regularly supervise students on SSC attachments and as part of the INSPIRE research programme. I am also a personal and academic (PATS) tutor for medical students.

I am particularly keen to encourage medical students to undertake research during their time at medical school and welcome any enquiries regarding potential projects.

Current Projects

I am presently involved in a SOPHIA (Sampling and biomarker OPtimization and Harmonization In ALS and other motor neuron diseases) sponsored project examining the use of the motor unit number index (MUNIX) as a longitudinal biomarker in motor neuron disease. The hope is that this technique will be more sensitive at detecting disease progression than previous markers.



I am also undertaking work on the electrodiagnostic stratification of patients with motor neuron disease and contribute to a study examining the use of magnetic resonance imaging (MRI) in motor neuron disease.


Selected Publications

Alix JJ, Hadjivassiliou M, Ali R, Slater D, Messenger AG, Rao DG. Sensory ganglionopathy with livedoid vasculopathy controlled by immunotherapy. Muscle Nerve. 2015;51(2):296-301

Alix JJ, Kandler RH, Mordekar SR. The value of long term EEG monitoring in children: a comparison of ambulatory EEG and video telemetry. Seizure. 2014;23(8):662-5.

Goodwin E, Kandler RH, Alix JJ. The value of home video with ambulatory EEG: a prospective service review. Seizure. 2014;23(6):480-2

Alix JJ, Zammit C, Riddle A, Meshul CK, Back SA, Valentino M, Fern R. Central axons preparing to myelinate are highly sensitive to ischemic injury. Ann Neurol. 2012;72(6):936-51

Alix JJ, Domingues AM. White matter synapses: form, function, and dysfunction. Neurology. 2011;76(4):397-404

Alix JJ. Clinician-scientist training: a perspective from across the pond. Ann Neurol. 2010;68(1):119-20

Alix JJ, Fern R. Glutamate receptor-mediated ischemic injury of premyelinated central axons. Ann Neurol. 2009;66(5):682-93

Professional Activities

Module Leader, Applied Neuroanatomy & Clinical Neuroscience module, MSc Neurology course, University of Sheffield

Ad hoc peer review for journals, including Muscle and Nerve and the European Journal of Neurology.

Biography & Awards

2015 – Present:
NIHR Academic Clinical Lecturer in Neurophysiology, University of Sheffield

2012 – 2014:   
Specialty Registrar in Clinical Neurophysiology, Yorkshire and the Humber Deanery

2010 – 2012:   
NIHR Academic Clinical Fellowship in Core Medical Training/Neurology, University of Sheffield

2008 – 2010:   
Academic Foundation Programme, Imperial College, London

2000 – 2008:   
MB/PhD programme, University of Leicester Medical School

I studied medicine at Leicester Medical School, completing an intercalated BSc in neuroscience (1st class Hons) before moving onto the MB/PhD programme. I completed my PhD under the supervision of Prof. Robert Fern (now Univ. of Plymouth) on the molecular mechanisms of perinatal white matter injury. After graduating I gained further research experience in the laboratory of Prof Stephen Back (OHSU, USA) before commencing academic foundation programme training in London. Alongside clinical work I completed a research attachment with Prof. Richard Reynolds (Imperial College, London) before moving to Sheffield to take up an NIHR academic clinical fellowship. Since arriving in Sheffield I have continued my training as a clinician-scientist under the supervision of Prof. Dame Pamela Shaw.    


NIHR Academic Clinical Lectureship, University of Sheffield, 2015

NIHR Academic Clinical Fellowship, University of Sheffield, 2010

Distinction, Final Professional Examination, University of Leicester, 2008

Wellcome Trust Elective Prize, 2008

Physiology Society Studentship, 2005

Leicester Medical Research Foundation (Medisearch) Studentship, 2004

Charles Lawson Award for Intercalated Studies, University of Leicester, 2004


Academic Neurology Unit
Department of Neuroscience
Sheffield Institute for Translational Neuroscience
University of Sheffield
Room B35
385a Glossop Road
S10 2HQ

Tel: +44 (0)114 22 222
Fax: +44 (0)114 22 22290