Sheffield Institute for
Translational Neuroscience

Professor Christopher McDermott MBChB FRCP PhD

Head of Department

Professor of Translational Neurology

Honorary Consultant Neurologist


Research Interests

The main drive of Prof McDermott’s research programme is developing the evidence base for delivering supportive and symptomatic care for patients living with motor neuron disease. He is also interested in studying mechanisms of neurodegeneration, in order to develop treatments for patients with motor neuron disease and hereditary spastic paraplegia.

Current Projects

 Current Projects

  • Investigating optimal respiratory support for patients with MND
  • Establishing an evidence base for nutritional support in MND
  • Designing and evaluating assistive technologies for patients with neuromuscular weakness
  • Developing and evaluating novel service delivery mechanisms for patients with long term neurological conditions
  • Genetic and phenotypic characterisation of motor system disorders
  • Natural history study of motor system disorders
  • Collaborating with pharmaceutical companies in Phase 1-3 studies
  • Improving symptomatic management for patients with MND
  • Epidemiology of motor neuron disease

Principal Funding Sources:

  • Motor Neurone Disease Association, UK
  • National Institute of Health Research (NIHR)
  • Marie Curie
  • European Union

Research Team

  • Esther Hobson
  • Theocharis Stavroulakis
  • Helen Wolff
  • Mbombe Kazoka
  • Lee Tuddenham
  • Sarah Boddy

Publications

Representative Publications:

Oliver, D., Radunovic, A., Allen, A., & McDermott, C. (2017). The development of the UK National Institute of Health and Care Excellence evidence-based clinical guidelines on motor neurone disease. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. doi:10.1080/21678421.2017.1304558

Stavroulakis, T., & McDermott, C. J. (2017). Nutritional Support in Amyotrophic Lateral Sclerosis. In E. M. Arsava (Ed.), Nutrition in Neurologic Disorders A Practical Guide. Springer. doi:10.1007/978-3-319-53171-7_6

Baxter, S. K., & McDermott, C. J. (2017). Decision-making and referral processes for patients with motor neurone disease: a qualitative study of GP experiences and evaluation of a new decision-support tool. BMC Health Services Research17. doi:10.1186/s12913-017-2286-0

McGeachan, A. J., & Mcdermott, C. J. (2017). Management of oral secretions in neurological disease.. Practical Neurology17(2), 96-103. doi:10.1136/practneurol-2016-001515

Hobson, E. V., Fazal, S., Shaw, P. J., & McDermott, C. J. (2017). “Anything that makes life’s journey better.” Exploring the use of digital technology by people living with motor neurone disease. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. doi:10.1080/21678421.2017.1288253

Gardiner, C., McDermott, C., & Hulme, C. (2017). Costs of Family Caregiving in Palliative Care (COFAC) questionnaire: development and piloting of a new survey tool.. BMJ Supportive and Palliative Care. doi:10.1136/bmjspcare-2016-001202

Pancani, S., Tindale, W., Shaw, P. J., McDermott, C. J., & Mazza, C. (2017). An Objective Functional Characterisation of Head Movement Impairment in Individuals with Neck Muscle Weakness Due to Amyotrophic Lateral Sclerosis. PLoS One. doi:10.1371/journal.pone.0169019

Oliver, D., Radunovic, A., Allen, A., & McDermott, C. (2017). The development of the UK National Institute of Health and Care Excellence evidence-based clinical guidelines on motor neurone disease. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. doi:10.1080/21678421.2017.1304558

Stavroulakis, T., & McDermott, C. J. (2017). Nutritional Support in Amyotrophic Lateral Sclerosis. In E. M. Arsava (Ed.), Nutrition in Neurologic Disorders A Practical Guide. Springer. doi:10.1007/978-3-319-53171-7_6

Baxter, S. K., & McDermott, C. J. (2017). Decision-making and referral processes for patients with motor neurone disease: a qualitative study of GP experiences and evaluation of a new decision-support tool. BMC Health Services Research17. doi:10.1186/s12913-017-2286-0

McGeachan, A. J., & Mcdermott, C. J. (2017). Management of oral secretions in neurological disease.. Practical Neurology17(2), 96-103. doi:10.1136/practneurol-2016-001515

Hobson, E. V., Fazal, S., Shaw, P. J., & McDermott, C. J. (2017). “Anything that makes life’s journey better.” Exploring the use of digital technology by people living with motor neurone disease. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. doi:10.1080/21678421.2017.1288253

Gardiner, C., McDermott, C., & Hulme, C. (2017). Costs of Family Caregiving in Palliative Care (COFAC) questionnaire: development and piloting of a new survey tool.. BMJ Supportive and Palliative Care. doi:10.1136/bmjspcare-2016-001202

Pancani, S., Tindale, W., Shaw, P. J., McDermott, C. J., & Mazza, C. (2017). An Objective Functional Characterisation of Head Movement Impairment in Individuals with Neck Muscle Weakness Due to Amyotrophic Lateral Sclerosis. PLoS One. doi:10.1371/journal.pone.0169019

DiPALS Writing Committee; DiPALS Study Group Collaborators. Safety and efficacy of diaphragm pacing in patients with respiratory insufficiency due to amyotrophic lateral sclerosis (DiPALS): a multicentre, open-label, randomized controlled trial. Lancet Neurol. 2015 Sep;14(9):883-92. doi:10.1016/S1474-4422(15)00152-0. Epub 2015 Jul 30. PubMed PMID: 26234554.

Reed H, Langley J, Stanton A, Heron N, Clarke Z, Judge S, McCarthy A, Squire G, Quinn A, Wells O, Tindale W, Baxter S, Shaw PJ, McDermott CJ. Head-Up; An interdisciplinary, participatory and co-design process informing the development of a novel head and neck support for people living with progressive neck muscle weakness. J Med Eng Technol. 2014;39:404-10.

Rafiq MK, Lee E, Bradburn M, McDermott CJ, Shaw PJ. Effect of lipid profile on prognosis in the patients with amyotrophic lateral sclerosis: Insights from the olesoxime clinical trial. Amyotroph Lateral Scler Frontotemporal Degener. 2015 Dec;16(7-8):478-84. doi: 10.3109/21678421.2015.1062517. Epub 2015 Jul 10. PubMed PMID: 26161993.

Rafiq MK, Bradburn M, Proctor AR, Billings CG, Bianchi S, McDermott CJ, Shaw PJ. A preliminary randomized trial of the mechanical insufflator-exsufflator versus breath-stacking technique in patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. 2015 Dec;16(7-8):448-55. doi:10.3109/21678421.2015.1051992. Epub 2015 Jul 3. PubMed PMID: 26140500.

ProGas Study Group. Gastrostomy in patients with amyotrophic lateral sclerosis (ProGas): a prospective cohort study. Lancet Neurol. 2015 Jul;14(7):702-9. doi:10.1016/S1474-4422(15)00104-0. Epub 2015 May 28. PubMed PMID: 26027943; PubMed Central PMCID: PMC4578147.

McGeachan AJ, Hobson EV, Shaw PJ, McDermott CJ. Developing an outcome measure for excessive saliva management in MND and an evaluation of saliva burden in Sheffield. Amyotroph Lateral Scler Frontotemporal Degener. 2015 Mar;16(1-2):108-13. doi: 10.3109/21678421.2014.951942. Epub 2014 Sep 16. PubMed PMID: 25225845.

Jenkins TM, Hollinger H, McDermott CJ. The evidence for symptomatic treatments in amyotrophic lateral sclerosis. Curr Opin Neurol. 2014 Oct;27(5):524-31. doi:10.1097/WCO.0000000000000135. Review. PubMed PMID: 25110934.

Stavroulakis T, Baird WO, Baxter SK, Walsh T, Shaw PJ, McDermott CJ. The impact of gastrostomy in motor neurone disease: challenges and benefits from a patient and carer perspective. BMJ Support Palliat Care. 2014 May 21. pii: bmjspcare-2013-000609. doi: 10.1136/bmjspcare-2013-000609. [Epub ahead of print] PubMed PMID: 24848262.

Stavroulakis T, Baird WO, Baxter SK, Walsh T, Shaw PJ, McDermott CJ. Factors influencing decision-making in relation to timing of gastrostomy insertion in patients with motor neurone disease. BMJ Support Palliat Care. 2014 Mar;4(1):57-63. doi: 10.1136/bmjspcare-2013-000497. Epub 2013 Dec 11. PubMed PMID: 24644772.

Da Costa MM1, Allen CE, Higginbottom A, Ramesh T, Shaw PJ, McDermott CJ. Dis Model Mech.A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening.Dis Model Mech. 2014 Jan;7(1):73-81. doi: 10.1242/dmm.012013. Epub 2013 Oct 2.

Baxter SK, Baird WO, Thompson S, Bianchi SM, Walters SJ, Lee E, Ahmedzai SH, Proctor A, Shaw PJ, McDermott CJ.The impact on the family carer of motor neurone disease and intervention with noninvasive ventilation. J Palliat Med. 2013 Dec;16(12):1602-9.

Baxter SK, Baird WO, Thompson S, Bianchi SM, Walters SJ, Lee E, Ahmedzai SH, Proctor A, Shaw PJ, McDermott CJ. The use of non-invasive ventilation at end of life in patients with motor neurone disease: A qualitative exploration of family carer and health professional experiences. Palliat Med. 2013 Jun;27(6):516-23. doi: 10.1177/0269216313478449.Epub 2013 Mar 5.

Kirby J, Highley JR, Cox L, Goodall EF, Hewitt C, Hartley JA, Hollinger HC, Fox M, Ince PG, McDermott CJ, Shaw PJ. Lack of unique neuropathology in amyotrophic lateral sclerosis associated with p.K54E angiogenin (ANG) mutation.  Neuropathol Appl Neurobiol. 2012 Dec 10. doi: 10.1111/nan.12007. [Epub ahead of print]

Tomi Aridegbe, Ros Kandler, Theresa Walsh, Pamela J Shaw, Christopher J McDermott. The natural history of motor neurone disease: assessing the impact of specialist care. Amyotroph Lateral Scler. 2013;14:13-19

Ismail A, Cooper-Knock J, Highley JR, Milano A, Kirby J, Goodall E, Lowe J, Scott I, Constantinescu CS, Walters SJ, Price S, McDermott CJ, Sawcer S, CompstonDA, Sharrack B, Shaw PJ. Concurrence of multiple sclerosis and amyotrophic lateral sclerosis in patients with hexanucleotide repeat expansions of C9ORF72. J Neurol Neurosurg Psychiatry. 2013;84:79-87

Baxter SK, Baird WO, Thompson S, Bianchi SM, Walters SJ, Lee E, Ahmedzai SH, Proctor A, Shaw PJ, McDermott CJ. The initiation of non-invasive ventilation for patients with motor neuron disease: Patient and carer perceptions of obstacles and outcomes.  Amyotroph Lateral Scler. 2012;14:105-110.

Stavroulakis T, Walsh T, Shaw PJ, McDermott CJ; (on behalf of the Progas Study). Gastrostomy use in motor neurone disease (MND): A review, meta-analysis and survey of current practice. Amyotroph Lateral Scler. 2012;14:96-104.

McDermott C J, Maguire C, Cooper C L, Ackroyd R, Baird W O, Baudouin S, Bentley A, Bianchi S, Bourke S, Bradburn M J, Dixon S, Ealing J, Galloway S, Karat D, Maynard N, Morrison K, Mustfa N, Stradling J, Talbot K, Williams T and Shaw P J. Protocol for Diaphragm Pacing in patients with respiratory muscle weakness due to Motor Neurone Disease (DiPALS): a randomised controlled trial [Trial Registration: Current controlled trials ISRCTN53817913].  BMC Neurology. 2012;12:74

Muhammad K Rafiq, Michael Bradburn, Alison R Proctor, Catherine Billings, Stephen Bianchi, Christopher J McDermott, Pamela J Shaw. Using transcutaneous carbon dioxide monitor (TOSCA 500) to detect respiratory failure in patients with Amyotrophic Lateral Sclerosis: a validation study. Amyotroph Lateral Scler. 2012;13:528-532

Muhammad Khizar Rafiq, Alison Ruth Proctor, Christopher J McDermott, Pamela J Shaw. Respiratory management of motor neurone disease: a review of current practice and new developments. Practical Neurology. 2012;12:166-176.

Cooper-Knock J, Hewitt C, Highley JR, Brockington A, Milano A, Man S, McDermott CJ, Shaw PJ. Clinico-pathological features in amyotrophic lateral sclerosis with expansions in C9ORF72. Brain. 2012;135:751-764.

O'Neill CL, Williams TL, Peel ET, McDermott CJ, Shaw PJ, Gibson GJ, Bourke SC. Non-invasive ventilation in motor neuron disease: an update of current UK practice.  J Neurol Neurosurg Psychiatry. 2012;83:371-376

Al-Chalabi A, Shaw PJ, Young CA, Morrison KE, Murphy C, Thornhill M, . . . Leigh, PN. Protocol for a double-blind randomised placebo-controlled trial of lithium carbonate in patients with amyotrophic Lateral Sclerosis (LiCALS) [Eudract number: 2008-006891-31]. BMC Neurology. 2011;11. doi:10.1186/1471-2377-11-111

Chavada G, El-Nayal A, Lee F, Webber SJ, McAlindon M, Walsh T, Hollinger H, McDermott CJ, Shaw PJ. Evaluation of two different methods for per-oral gastrostomy tube placement in patients with motor neuron disease (MND): PIG versus PEG procedures.  Amyotroph Lateral Scler. 2010;11:531-536.

Hervé Besson, Ceryl A Harwood, Ulf Ekelund, Francis M Finucane, Christopher J McDermott, Pamela J Shaw, Nicholas J Wareham. Validation of the historical adulthood physical activity questionnaire (HAPAQ) against objective measurements of physical activity.  Int J Behav Nutr Phys Act. 2010;7:54-63.

Christopher Hewitt, Janine Kirby, J. Robin Highley, Judith A. Hartley; Rachael Hibberd, Hannah C. Hollinger, Tim L. Williams, Paul G. Ince, Christopher J. McDermott, Pamela J. Shaw. Novel FUS/TLS Mutations and Pathology in Familial and Sporadic Amyotrophic Lateral Sclerosis. Arch Neurol. 2010;67:455-461.

C Douglass, R Kandler, PJ Shaw and CJ McDermott. An evaluation of neurophysiological criteria used in the diagnosis of Motor Neurone Disease.  J Neurol Neurosurg Neuropsych 2010;81:646-9.

J Kirby, E Goodall W Smith, J R Highley, R Masanzu, JA Hartley, R Hibberd, HC Hollinger, SB Wharton, K Morrison, PG Ince, CJ McDermott and PJ Shaw. Broad clinical phenotypes associated with TAR-DNA binding protein (TARDBP) mutations in amyotrophic lateral sclerosis. Neurogenetics. 2010 May;11(2):217-25. doi: 10.1007/s10048-009-0218-9. Epub 2009 Sep 17.

RMC Trial Group. Randomised controlled trial of methotrexate for chronic inflammatory demyelinating polyradiculoneuropathy (RMC trial): a pilot, multicentre study. Lancet Neurol. 2009;8:158-64.

C Hewamadduma, C McDermott, J Kirby, A Grierson, M Panayi, A Dalton, Y Rajabally, P Shaw. New pedigrees and novel mutation expand the phenotype of REEP1-associated hereditary spastic paraplegia (HSP).  Neurogenetics. 2009;10:105-8

PR Kasher, KJ De Vos, SB Wharton, C Manser, EJ Bennett, M Bingley, JD Wood, R Milner, CJ McDermott, CC Miller, PJ Shaw, AJ Grierson. Direct evidence for axonal transport defects in a novel mouse model of mutant spastin-induced hereditary spastic paraplegia (HSP) and human HSP patients.  J Neurochem 2009;110:34-44.

CA Harwood, CJ McDermott, PJ Shaw. Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence. Amyotroph Lateral Sclerosis 2009;10:191-204

CJ McDermott and PJ Shaw. Diagnosis and management of motor neurone disease.  British Medical Journal 336:658-662;2008.

AA Hewamadduma, J Kirby, C Kershaw, Ann Dalton. CJ McDermott, PJ Shaw. HSP60 is a rare cause of hereditary spastic paraparesis, but may act as a genetic modifier.  Neurology 2008;170:1717-1718

C Beetz, S Zucher, A Ashgley-Koch, M Auer-Grumbach, P Byrne, PF Chinnery, M Hutchinson, CJ McDermott, IA Meyer, AOH Nygren, M Pericak-Vance, A Pyle, GA Rouleau, J Schickel, PJ Shaw, T Deufel. Linkage to a known gene, but no mutation identified: comprehensive re-analysis of SPG4 HSP pedigrees reveals large deletions as the sole cause. Human Mutation 28:739-40,2007.

JD Wood, JA Landers, M Bingley, CJ McDermott, V Thomas McArthur, LJ Gleadall, PJ Shaw, VT Cunliffe. The microtubule severing protein spastin is required for motor axon outgrowth in the zebrafish embryo. Human Molecular Genetics 15:2763-2771;2006.

CJ McDermott, CE Burness, J Kirby, LE Cox, G Rao, M Durkie, B Sharrack, M Hadjivassiliou, PF Chinnery, A Dalton, PJ Shaw on behalf of the UK and Irish HSP Consortium. Clinical features of hereditary spastic paraparesis due to spastin mutation. Neurology 67:45-51;2006

CJ McDermott, PJ Shaw. Hereditary spastic paraplegia.  In : Handbook of Handbook of Clinical Neurology Series 3rd Edition. Motor Neuron Disorders. Elsevier. Editors Andrew Eisen, Pamela J Shaw. Chapter 17:327-352, 2006.

CJ McDermott, AJ Grierson, JD Wood, M Bingley, KDM Bushby, PJ Shaw. Hereditary spastic paraparesis: evidence of disrupted intracellular transport associated with spastin mutation.  Ann Neurol 54:748-759;2003.

CJ McDermott, RW Taylor, C Hayes, M Johnson, KMD Bushby, DM Turnbull, PJ Shaw. Investigation of mitochondrial function in hereditary spastic paraparesis.  NeuroReport 14:485-488; 2003.

CJ McDermott, D Roberts, J Tomkins, KMD Bushby, PJ Shaw. Spastin and paraplegin analysis in selected cases of motor neuron disease with prominent upper motor neuron degeneration.  ALS and related Motor Neuron Disorders 11:1-4;2003.

CJ McDermott, PJ Shaw. Hereditary spastic paraparesis.  In: Blue Book of Practical Neurology. Editors PJ Shaw and M Strong. Chapter 18, 2003, pp 435-464. Butterworth Heinemann, Philadelphia.

CJ McDermott, PJ Shaw. Hereditary spastic paraparesis.  In: International Review of Neurobiology 53:191-204;2002: Mitochondrial Disorders of the Nervous System Editor A Schapira.
Update on motor neurone disease. CJ McDermott, PJ Shaw. Update 662-667;2002.

J Tomkins, SJ Banner, CJ McDermott, PJ Shaw. Mutation screening of manganese superoxide dismutase (SOD2) in amyotrophic lateral sclerosis (ALS).  NeuroReport 12:1-4; 2001.

CJ McDermott, RK Dayaratre, J Tomkins, MA Johnson, G Casari, DM Turnbull, KMD Bushby, PJ Shaw. Paraplegin gene analysis in hereditary spastic paraparesis pedigrees in the North East of England. Neurology 56:467-471;2001.

JC Lindsey, ME Lusher, CJ McDermott, KD White, E Reid, DC Rubinztein, R Bashir, PJ Shaw, KMD Bushby. Mutation analysis of the spastin gene in patients with hereditary spastic paraparesis.  J Med Genet 37:759-765;2000.

CJ McDermott, KD White, K Bushby, PJ Shaw. Hereditary spastic paraparesis: a review of new developments.  J Neurol Neurosurg Psychiatry 69:150-160;2000.

Professional Activities

Professional Experience

  • Head of Department, Neuroscience, University of Sheffield (2018 onwards)
  • Chair of Association of British Neurologists MND Special Interest Group (2017 onwards)
  • Member of Association of British Neurologists Neuromuscular Advisory Group (2018 onwards)
  • Deputy Director of NIHR BRC Sheffield (2017 onwards)
  • External Examiner Neuroscience MSc, Kings College London (2016 onwards)
  • Expert Advisor for NICE (2016 onwards)
  • Charitable Trustee for Neurocare (2016 onwards)
  • Group Leader for the International ALS Clinical Trials Guidelines (2015 onwards).
  • Chair of the NIHR DeNDRoN MND Clinical Studies Group (2015 onwards)
  • Chair of the MND Association Clinical Advisory Board (2015 onwards)
  • Member MND NICE Clinical Guidelines Development Group (2013 – 2016) and NICE Quality Assurance panel (2015 - 2016).
  • Founding Course Leader – Clinical Neurology MSc, University of Sheffield 2011-2015
  • Clinical Lead for Neurology, Sheffield Teaching Hospitals 2012-2014
  • Member of NIHR RfPB (2010-2014) and MNDA healthcare research grant panels (2014 onwards).
  • Representation of the Yorkshire and Humber region nationally on the Joint Royal College of Physician’s Specialty Advisory Committee (2008 - 2013).
  • Training Programme Director for Neurology Yorkshire and Humber (2008-2012)

Invited lectures:

2017

  • NICE Guidelines 1 year on Conference, London UK - Managing Symptoms in MND at the MND
  • Association British Neurologists Meeting, Liverpool - Right to try
  • MND Care Centre Meeting, Kettering - MyTube
  • NIHR Annual CRF conference, Glasgow - User Centred Design
  • Newcastle Neurosciences Meeting, Newcastle upon Tyne - MND A Journey through time and space
  • MND Scotland meeting, Stirling - MND Clinical Research update
  • Oxford Neurosciences Meeting, Oxford - MND Surviving the experts

2016

  • Manchester Regional Neurosciences Centre – The evidence base for supportive Care in ALS.
  • Newcastle upon Tyne, MND study day – Delivering evidence based care for individuals with ALS.
  • Sheffield MND Study day – Recent developments in ALS care.
  • St Christopher’s Hospice, London – Nutritional Care in ALS.
  • Primary Care 2016, NEC, Birmingham – NICE guidelines for primary care.

2015

  • British Thoracic Society, London – Diaphragmatic Pacing in ALS
  • Difficult Lung Disease symposium, Sheffield – Neuromuscular disease for the respiratory physician.
  • MNDA Care Centre meeting, Stafford - myNIV
  • Association of palliative medicine neurological palliative care specialist interest forum, Manchester – What is new in MND.
  • 1st UK PLS conference, Oxford – HSP and PLS
  • WFN ALS meeting, Orlando – DiPALS results

2014

  • MNDA Care Centre meeting, Stafford – Head Up
  • Royal Society Medicine, London – The evidence base for symptomatic care in ALS
  • MND Centre, Oxford – Update on symptomatic care.
  • The Walton Centre, Liverpool - Update on symptomatic care.
  • St Christopher’s Hospice, London – Head Up.
  • Royal College of Physicians Regional Update, Sheffield – Neurology for the physician.

2013

  • Plenary speaker: ENCALS, Sheffield - While we wait.
  • MND Care Centre Directors meeting, Birmingham – Head Up and Secretion management
  • St Christopher’s Hospice, London – Diaphragmatic Pacing
  • The Walton Centre Regional Neurosciences Centre, Liverpool – Respiratory management of MND

2012

  • Edinburgh Regional Neurosciences Centre - Respiratory management of MND
  • Home Mechanical Ventilation Meeting, St Thomas Hospital, London – Role of Diaphragmatic Pacing
  • Palliative Care Symposium, Leeds – Living with MND
  • MNDA AGM – Developing the evidence base for clinical care in MND

2011

  • Association of British Neurologists meeting – Clinical advances in MND
  • European federation of neurological sciences, Lisbon – MND and its mimics

2010

  • European Federation of Neurological Sciences, Rhodes - Lump or Split?
  • MNDA Birmingham – Diaphragmatic Pacing in MND
  • Nutrition Course, Leeds – Nutrition in MND

2009

  • Leeds MNDA centre opening – Hereditary spastic paraparesis

Biography

Prof McDermott studied for his medical degree at the University in Leeds graduating in 1994. He then continued is general medical and specialist neurology training in Leeds before taking up a clinical research training fellowship at the University of Newcastle upon Tyne. He moved to the University of Sheffield with Professor Dame Pamela Shaw in 2000 to undertake his Wellcome Trust Research Training PhD Fellowship and to complete his Specialist Training in Neurology to become a Consultant Neurologist in 2006. Prof McDermott is now the Professor of Translational Neurology at SITraN and a Consultant Neurologist at the Sheffield Teaching Hospitals Foundation NHS Trust regularly undertaking specialist MND and neuromuscular clinics in Sheffield.

2018 - Present
Professor of Translational Neurology
Head of Department

2017 - 2018
Professor of Translational Neurology
Academic Director for Neuroscience, Sheffield Teaching Hospitals NHS Foundation Trust

2014 - 2016
Reader in Neurology
Academic Director for Neuroscience, Sheffield Teaching Hospitals NHS Foundation Trust

2006 - 2013
Clinical Senior Lecturer in Neurology

2002 - 2006
Specialist Training in Neurology (CCT), Sheffield

2000 - 2002
Wellcome Trust Research Training Fellowship (PhD), University of Sheffield

1998 - 2000
Clinical Research Fellow, University of Newcastle upon Tyne

1997 - 1998
Specialist Training in Neurology, Leeds

1994 - 1997
General professional training (MRCP), Leeds Teaching Hospitals

1989 - 1994
Medicine (MBChB), University of Leeds

Contact Details

T: +44 (0)114 22 22295
F: +44 (0)114 22 22290
E: c.j.mcdermott@sheffield.ac.uk

Medical NHS Secretary
Erica Waines
T: +44 (0)114 2261049
E: Erica.Waines@sth.nhs.uk
Royal Hallamshire Hospital
Glossop Road
Sheffield
United Kingdom, S10 2JF

Academic Secretary
Bev Carter
T: +44(0)114 22 22295
E: bev.carter@sheffield.ac.uk
University of Sheffield
Faculty of Medicine, Dentistry and Health
Department of Neuroscience
Sheffield Institute for Translational Neuroscience
385a Glossop Road
Sheffield
United Kingdom, S10 2HQ