Sheffield Institute for
Translational Neuroscience

Dr Jessica Redgrave

Clinical Lecturer in Neurology


Research Interests

Dr Redgrave's research interest is in carotid plaque instability. She is now building a programme of research in Sheffield to study novel markers of vulnerable carotid plaque. She is particularly interested in the role of red blood cell membrane cholesterol as a determinant of carotid plaque instability after intra-plaque haemorrhage.

Her other main interest is in factors which delay patients with stroke and TIA calling for medical assistance after symptoms onset. She has set up the ongoing Stroke and TIA and Response to Symptoms Study (S.T.A.R.S.) - an observational study of consecutive patients attending hospital with stroke / TIA in Sheffield (population 500,000). S.T.A.R.S. seeks to determine patients’ awareness of the FAST campaign and the barriers to help-seeking which need to be addressed by media campaigns.

Current Projects

I am investigating the role of red blood cell membrane cholesterol content as a potential new biomarker of unstable carotid plaque.
I am collaborating with Prof Iain Wilkinson and Dr Nigel Hoggard (Radiology), Dr Robert Hill (Clinical Chemistry), Dr Kim Suvarna (Histopathology) and Prof Jonathan Beard (Vascular Surgery) on a NeuroCare Grant and have commenced data collection for this project.

I am also working on Stroke and TIA Awareness and Response to Symptoms Study (S.T.A.R.S.) as principal investigator in collaboration with
Prof. Rothwell (Oxford), Prof. Norman and Prof. Goyder (Sheffield).

Publications

  1. Howard D, van Lammeren G, Rothwell P, Redgrave J, Moll F, de Vries J-P, de Kleijn D, den Ruijter H, Jan de Borst G, Pasterkamp G. Symptomatic carotid atherosclerotic disease: correlations between plaque composition and ipsilateral stroke risk Stroke 2014 In press
  2. van Lammeren G, Howard D, Rothwell PM, Redgrave JN, Moll F, de Vries J-P, de Kleijn D, den Ruijter H, Jan de Borst G, and Pasterkamp G Symptomatic carotid atherosclerotic disease: correlations between plaque composition and ipsilateral stroke risk. (Journal American Heart Association 2014 in press)
  3. Howard DP, van Lammeren GW, Redgrave JN, Moll FL, de Vries JP, de Kleijn DP, de Borst GJ, Pasterkamp G, Rothwell PM. Histological features of carotid plaque in patients with ocular ischemia versus cerebral events. Stroke. 2013 Mar;44(3):734-9.
  4. Lovelock CR, Redgrave JN, Briley D, Rothwell PM. The SCAN rule-a clinical rule to reduce CT misdiagnosis of intracerebral haemorrhage in minor stroke. JNNP 2010; 81(3); 271-5.
  5. Redgrave JN, Lovett JK, Rothwell PM. Histological features of symptomatic carotid plaques in relation to age and smoking: the oxford plaque study. Stroke2010; 41(10):2288-94.
  6. Lovelock CR, Redgrave JN, Briley D, Rothwell PM. Reliable Estimation of the Proportion of Minor Stroke due to Intracerebral Haemorrhage Int J Stroke2009:4 (1); 6-10.
  7. Redgrave JN, Gallagher PJ, Lovett JK, Rothwell PM. Critical cap thickness and rupture in symptomatic carotid plaques Stroke 2008; 39 (6):1722-9.
  8. Flossmann E, Redgrave JN, Briley D, Rothwell PM. Reliability of clinical diagnosis of the symptomatic vascular territory in patients with recent TIA or minor stroke Stroke 2008; 39 (9) 2457-60.
  9. Redgrave JN, Gallagher PJ, Lovett JK, Rothwell PM Fibrous Cap Thickness and Rupture in Carotid Atheromata: Still Hunting in the Dark? (Response) Stroke 2008; 39: e191 - e192.
  10. Redgrave JN, Lovett JK, Gallagher PJ, Rothwell PM. Histological Characteristics of Vulnerable Carotid Plaque. Circulation 2007; 114: e599.
  11. Redgrave JN, Rothwell PM. Asymptomatic Carotid Stenosis: what to do Curr Opin Neurol  2007; 58-64.
  12. Redgrave JN, Lovett JK, Gallagher PJ, Rothwell PM. Symptomatic Carotid Plaques and Ischaemic Symptoms. Cardiology Review. 2007; 24:30-35.
  13. Redgrave JN, Coutts S, Schulz UG, Briley D, Rothwell PM. Systematic Review of Associations between acute ischaemic lesions on diffusion-weighted imaging and clinical predictors of early stroke risk after TIA Stroke 2007; 38:1482-1488.
  14. Redgrave JN, Schulz UG, Briley D, Meagher T, Rothwell PM. Presence of acute ischaemic lesions on DWI is associated with clinical predictors of early stroke risk after TIA. Cerebrovasc Dis 2007;23;24(1):86-90.
  15. Schulz UG, Flossmann E, Francis J, Redgrave JN, Rothwell PM. Evolution of the diffusion-weighted signal and the Apparent Diffusion Coefficient in the late phase after minor stroke: a follow-up study J Neurol  2007; 254:375-383.
  16. Mazzucco S, Redgrave JN, et al. Asymptomatic recurrent DWI lesions in the subacute and chronic phase after TIA or minor stroke. Cerebrovasc Dis 2007;11;24(1):133-135.
  17. Rothwell PM, Giles MF, Chandratheva A, Marquardt L, Geraghty O, Redgrave JN, et al; Effect of urgent treatment of transient ischaemic attack and minor stroke on early recurrent stroke; a prospective population-based sequential comparison Lancet. 2007 20; 370 (9596):1432-4.
  18. Redgrave JN, Lovett JK, Gallagher PJ, Rothwell PM. Histological assessment of 526 symptomatic carotid plaques in relation to the nature and timing of ischemic symptoms: the Oxford plaque study. Circulation 2006;113(19):2320-8.
  19. Rothwell PM, Coull AJ, Silver LE, Fairhead JF, Giles MF, Lovelock CE, Redgrave JN, et al. Population-based study of event-rate, incidence, case fatality, and mortality for all acute vascular events in all arterial territories (Oxford Vascular Study). Lancet  2005;366(9499):1773-83.
  20. Rothwell PM, Giles MF, Flossmann E, Lovelock CE, Redgrave JN, Warlow CP, Mehta Z. A simple score (ABCD) to identify individuals at high early risk of stroke after TIA. Lancet 2005;366 (9479):29-36.
  21. Lovett JK, Redgrave JN, Rothwell PM. A critical appraisal of the performance, reporting, and interpretation of studies comparing carotid plaque imaging with histology. Stroke 2005; 36(5):1091-7.
  22. Redgrave JN, Gallagher PJ, Lovett JK, Rothwell PM Histological Features of Symptomatic Carotid Plaques in Patients with Impaired Glucose Tolerance and Diabetes Cerebrovasc Dis 2008; 26 (1):79-86.

Professional Activities

Professional Memberships

  • British Association Stroke Physicians, September 2009 – Present
  • Association of British Neurologists, June 2004 – Present
  • Royal College of Physicians, August 2003 – Present


Positions of Responsibility

  • Marker of course essays on Stroke for MSc Clinical Neurology Course, Sheffield December 2013
  • Neurology SpR Representative at Consultant Meetings March 2012 – September 2012
  • Thrombolysis co-ordinator, Royal Hallamshire Hospital, Sheffield 2008-2010. Responsible for induction of new SpRs, thrombolysis training, and monthly audit of decision-making in thrombolysis situations.
  • First Dose Assessor for trial of FTY720 (fingolimod) in patients with relapsing remitting MS 2009.
  • Peer reviewer for journals including Circulation, Stroke, Journal of Neuroradiology (2006-present).
  • Clinician member of a panel that interviewed sixth-form students for the undergraduate medicine course, University of Oxford in 2006. Assessed problem solving ability, ethical awareness, and special interests.
  • President of the Junior Doctors Mess and PRHO Representative, University Hospital of Hartlepool, 2001. Contributed to meetings of the Junior Doctors Forum and Local Implementation Group.

Biography

Dr Jessica Redgrave joined SITraN as Clinical Lecture in Neurology in August 2013.

Dr Redgrave's doctorate research was undertaken at the Stroke Prevention Research Unit (SPRU) at the University of Oxford under the supervision of Professor Peter Rothwell.

During her time in Oxford, SPRU devised and validated the ABCD2 score which predicts the very early risk of stroke after a transient ischaemic attack (TIA). This score is now used worldwide in the management of patients with TIA.

The team also demonstrated the benefits of rapid treatment of patients with transient ischaemic attack, in order to prevent stroke and this work has informed national clinical care guidelines.

Awards

  • Medico-Chirurgical Society Elective Award, March 2000
  • General Practice Audit Prize, August 1999

Contact Details

Sheffield Institute for Translational Neuroscience
Department of Neuroscience
University of Sheffield
385a Glossop Road
Sheffield
S10 2HQ

T: +44 (0)114 222 2267
F: +44 (0)114 222 2290
E: Jessica.Redgrave@
sth.nhs.uk