Sheffield Institute for
Translational Neuroscience


The aim of the MUSCLE ENERGY project is to develop imaging biomarkers in Motor Neuron Disease (MND).

A biomarker is a measurement used to help diagnosis, monitor disease progress or predict outcome. Biomarkers are very important in conditions like MND in order to help test new medicines over affordable timescales, and can also help us understand how a disease develops. At present, no useful biomarker exists in MND. In this project, patients and healthy volunteers have a magnetic resonance imaging (MRI) scan either of their whole body to look at the muscles, or a specialised scan of the brain called spectroscopy to measure energy levels. This is compared with measures of muscle strength and electrical tests of the power of the muscles.

We are currently recruiting people to help with this research.

If you think you might be interested and would like further information, please contact Dr Tom Jenkins, Clinical Lecturer in Neurology to Professor Pamela Shaw on 0114 222 2261 or email 


Chief Investigator:
Dr Tom Jenkins
T: +44 (0) 114 222 2268