Sheffield Institute for
Translational Neuroscience

Cerebrospinal fluid samples showed that tofersen lowered levels of SOD1 protein and neurofilament markers of neuronal damage in patients compared to placebo. 

This first demonstration of biomarkers of efficacy in a clinical trial for MND are expected to have a great impact on clinical trials in future. 

The results of the study published in the New England Journal of Medicine (linked here) attracted a large amount of media interest:

BBC News Online
BBC One Breakfast (item starts: 14:14)

Financial Times
Sky News
The Guardian - page 11 (PDF available)
The Times - page 14 (PDF available)
Daily Mail
Daily Express - page 19 (PDF available)
The Independent
The i - page 16 (PDF available)
BBC Radio 4 Today Programme (items at 34:00, 1:35:00, 2:09:00 and 2:56:31)
BBC Radio 4 The World Tonight (item starts: 28:06)
BBC Radio Five Live Breakfast (item starts: 2:27:44)
BBC Radio Five Live news bulletins (item starts: 1:02:46)
BBC Radio Scotland (item starts: 2:40:25)
BBC World Service (item starts: 03:36)
The Herald Scotland - page 11 (PDF available)
London Evening Standard
Yahoo News UK and Ireland
Yorkshire Live
Shropshire Star
Press and Journal
The Courier
Express and Star
Belfast Telegraph
Telegraph and Argus
Lancashire Telegraph
Northern EchoBBC News Outside Source (item starts: 51:49)
BBC World Service Radio (item starts: 19:28)
The Telegraph - page 12 (PDF available)
Daily Mirror - page 26 (PDF available)
Evening Standard
BBC Look North (item starts: 16:14)
ITV Calendar (item starts: 10:40)
National World
Yahoo News
BBC Radio Sheffield (item starts: 1:17:37)
BBC Radio Foyle (item starts: 1:19:38)
BBC Radio Sussex (item starts: 3:45:41)
BBC Radio Wales news bulletins (item starts: 1:02:33)
IFL Science
Watford Observer
Oldham Times
Falmouth Packet
Oxford Mail